p38-MAPK inhibitor SB 239063, Purity ≥98%

Synonym: 193551-21-2; SB 239063; SB-239063; SB239063; Cyclohexanol, 4-(4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-; Trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole; p38-MAPK inhibitor

MDL: MFCD03792786
CAS Number: 193551-21-2
Compound CID: 5166

Product Size

2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 239063, soluble in DMSO and warmed ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

368.4

Molecular Formula

C₂₀H₂₁FN₄O₂

Targets

p38α: 44 nM; p38β: 44 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 59 mg/mL (160.15 mM); Water: Insoluble; Warmed ethanol: 7 mg/mL (19 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SB 239063 is utilized to study the inhibition of the p38 MAP kinase pathway with a focus on inflammation and cellular stress response.

Storage

Store at -20ºC.