p38-MAPK inhibitor TAK-715, Purity ≥98%

Synonym: TAK-715; 303162-79-0; TAK 715; N-(4-(2-ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide; TAK715; R-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-Benzamide; p38-MAPK inhibitor

MDL: MFCD17012805
CAS Number: 303162-79-0
Compound CID: 9952773

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TAK-715, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets ERK1, IKKβ, JNK1, and MEKK1.

Molecular Weight

399.51

Molecular Formula

C₂₄H₂₁N₃OS

Targets

ERK1: >10 μM; IKKβ: >10 μM; JNK1: >10 μM; MEKK1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 72 mg/mL (180.22 mM); Water: Insoluble; Ethanol: 14 mg/mL (35.04 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

TAK-715 can be used to study p38 MAP kinase inhibition and its effects on inflammatory disease models.

Storage

Store at -20ºC.