p38-MAPK inhibitor VX-702, Purity ≥98%

Synonym: VX-702; 745833-23-2; 479543-46-9; VX 702; VX702; 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide; 1-(5-Carbamoyl-6-(2,4-difluorophenyl)pyridin-2-yl)-1-(2,6-difluorophenyl)urea; p38-MAPK inhibitor

MDL: MFCD11616590
CAS Number: 479543-46-9, 745833-23-2
Compound CID: 10341154

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

VX-702, soluble in DMSO and insoluble in ethanol and water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38 activation.

Molecular Weight

404.3

Molecular Formula

C₁₉H₁₂F₄N₄O₂

Targets

p38 activation: 4-20 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (190.45 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

VX-702 can be used to study the effects of p38 MAP kinase inhibition in inflammatory and autoimmune diseases.