p53 activator Tenovin-1, Purity ≥98%

Synonym: 380315-80-0; Tenovin-1; Tenovin 1; N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide; N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide; p53 activator

MDL: MFCD02914760
CAS Number: 380315-80-0
Compound CID: 1013376

Product Size

25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Tenovin-1, soluble in DMSO and insoluble in ethanol and water, is a potent and selective p53-activating compound. It targets p53 and MDM2.

Molecular Weight

369.5

Molecular Formula

C₂₀H₂₃N₃O₂S

Targets

p53; MDM2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 65 mg/mL (175.92 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Tenovin-1 is used to study the inhibition of deacetylase enzymes SIRT1 and SIRT2 and their roles in cancer cell apoptosis and proliferation.