p53 inhibitor RG7112, Purity ≥98%

Synonym: 939981-39-2; RG7112; RG-7112; RO5045337; RO-5045337; RG 7112; Mdm2 antagonist ro5045337; ((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone; p53 inhibitor

CAS Number: 939981-39-2
Compound CID: 57406853

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

RG7112, soluble in DMSO and ethanol and insoluble in water, is an inhibitor of p53-mediated apoptosis and p53-dependent gene transcription.

Molecular Weight

727.78

Molecular Formula

C₃₈H₄₈Cl₂N₄O₄S

Form

Lyophilized powder

Purity

Solubility

DMSO: 97 mg/mL (133.55 mM); Water: Insoluble; Ethanol: 97 mg/mL (133.55 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

RG7112 can be researched for its potential to deactivate MDM2, thereby stabilizing p53 and inducing cancer cell death.