p53 inhibitor RG7112, Purity ≥98%

Synonym: 939981-39-2; RG7112; RG-7112; RO5045337; RO-5045337; RG 7112; Mdm2 antagonist ro5045337; ((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone; p53 inhibitor

CAS Number: 939981-39-2
Compound CID: 57406853

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RG7112, soluble in DMSO and ethanol and insoluble in water, is an inhibitor of p53-mediated apoptosis and p53-dependent gene transcription.

Molecular Weight

727.78

Molecular Formula

C₃₈H₄₈Cl₂N₄O₄S

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 97 mg/mL (133.55 mM); Water: Insoluble; Ethanol: 97 mg/mL (133.55 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

RG7112 can be researched for its potential to deactivate MDM2, thereby stabilizing p53 and inducing cancer cell death.

Storage

Store at -20ºC.