PAK inhibitor, FRAX1036, Purity ≥98%

Synonym: 1432908-05-8; FRAX-1036; FRAX 1036; 6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-one

CAS Number: 1432908-05-8
Compound CID: 71557891

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

FRAX1036, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting PAK. It targets the PAK1, PAK2, and PAK4.

Molecular Weight

518.05

Molecular Formula

C₂₈H₃₂ClN₇O

Targets

PAK1: 23.3 nM (Ki); PAK2: 72.4 nM (Ki); PAK4: 2.4 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: insoluble; Water: insoluble; Ethanol: 17 mg/mL (32.81 mM)

Applications

FRAX1036 is a cytoskeletal signaling inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of cancers by targeting the PAK1 pathway involved in cell proliferation and survival.