PAK inhibitor, FRAX486, Purity ≥98%

Synonym: 1232030-35-1; FRAX 486; FRAX-486; 6-(2,4-Dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one

CAS Number: 1232030-35-1
Compound CID: 68060125

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

FRAX486, soluble in DMSO and insoluble in water and ethanol, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting PAK. It targets the PAK1, PAK2, PAK3, and PAK4.

Molecular Weight

513.39

Molecular Formula

C₂₅H₂₃Cl₂FN₆O

Targets

PAK1: 14 nM; PAK2: 33 nM; PAK3: 39 nM; PAK4: 575 nM

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 21 mg/mL (40.9 mM); Water: insoluble; Ethanol: insoluble

Applications

FRAX486 is a cytoskeletal signaling inhibitor that plays a key role in cell growth, motility, and survival.