PAK inhibitor, KPT 9274, Purity ≥98%

Synonym: 1643913-93-2; ATG-019; (E)-3-(6-Aminopyridin-3-yl)-N-[[5-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide

MDL: MFCD30207881
CAS Number: 1643913-93-2
Compound CID: 117779453

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

KPT 9274, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting PAK.

Molecular Weight

610.63

Molecular Formula

C₃₅H₂₉F₃N₄O₃

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 85 mg/mL (139.2 mM); Water: insoluble; Ethanol: 85 mg/mL (139.2 mM)

Applications

KPT 9274 is a cytoskeletal signaling inhibitor that can be used for its ability to inhibit the export of tumor suppressor proteins and other key regulators from the nucleus to the cytoplasm, which can enhance antitumor activity.