PAK inhibitor, LOR-253, Purity ≥98%

Synonym: 916151-99-0; LOR 253; LOR253; APTO-253; 2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

CAS Number: 916151-99-0
Compound CID: 11960271

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LOR-253, soluble in DMSO and insoluble in water and ethanol, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting PAK.

Molecular Weight

367.38

Molecular Formula

C₂₂H₁₄FN₅

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 72 mg/mL (195.98 mM); Water: insoluble; Ethanol: insoluble

Applications

LOR-253 is a cytoskeletal signaling inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of various cancers and fibrotic diseases by blocking TGF-β signaling, which plays a role in tumor progression and fibrosis.