PAK inhibitor, PF-3758309, Purity ≥98%

Synonym: 898044-15-0; PF-03758309; N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide

MDL: MFCD18633226
CAS Number: 898044-15-0
Compound CID: 25227462

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF-3758309, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting PAK. It targets the PAK1, PAK6, PAK2, and PAK3.

Molecular Weight

490.2

Molecular Formula

C₂₅H₃₀N₈OS

Targets

PAK1: 13.7 nM (ki); PAK6: ki: 17.1 nM; PAK2: 190nM; PAK3: 99 nM

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 87 mg/mL (177.32 mM); Water: insoluble; Ethanol: 87 mg/mL (177.32 mM)

Applications

PF-3758309 is a cytoskeletal signaling inhibitor that can be used for its inhibition by PF-3758309 aims to disrupt cancer cell invasion and metastasis.