As a human milk oligosaccharide, the biological activities of para-lacto-N-neohexaose (pLNnH) and its derivatives have attracted more and more attention from biological science researchers. As a trusted operator, CD BioGlyco provides you with advanced services for pLNnH production.
Human milk oligosaccharides (HMOs) are recognized as having many excellent biological functions that benefit breastfed infants. It has become a popular trend for researchers to focus on synthesizing HMOs and imitating their natural diversity for formulation studies. Oligosaccharides of human milk can be classified into seven groups by the structures of their core oligosaccharides, which include lactose, lacto-N-octaose, lacto-N-neooctaose, lacto-N-hexaose, lacto-N-neohexaose, and so on. pLNnH is a derivative of lacto-N-neohexose, extracted from human milk. Researchers have studied and explored the biological activities and synthesis of pLNnH and its related derivatives to discover the application value of this compound in medicine, food, and other fields.
Fig.1 The structure of pLNnH. (CD BioGlyco)
The research on fucosylated derivatives of pLNnH has also become extensive. Purification of milk samples of a beluga and Minke whales by preparative thin layer chromatography, gel filtration, high-performance liquid chromatography, and ion-exchange chromatography recently. Two new types of oligosaccharides were found in the milk of minke whales, namely sialyl lacto-N-neotetraose and sialyl pLNnH. From a biological point of view, the researchers speculate that oligosaccharides extracted from minke whale milk may act as some anti-infection factors to protect lactating young whales from bacteria and viruses. And a derived structure was extracted from hooded seal milk, Crystophora cristata, which is Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc (monofucosyl pLNnH). There have been reports on the synthesis of fucosylated pLNnH using enzyme mutants, which provides a practical method for the study of future biological applications.
CD BioGlyco has accumulated a variety of Production Solutions to meet changing client needs, including but not limited to the following technologies. It is hereby declared that the pLNnH we offer should only be used as laboratory reagents for research and development.
Various high-grade standards and fully optimized separation routes.
Including fermentation, enzyme screening, and enzyme evolution for all biocatalysis challenges.
A complete and mature service product line from strain development to mass manufacturing.
CD BioGlyco provides high-quality production services of pLNnH, and we are delighted to work with our clients to help them meet their changing needs. If you want to know more details, please feel free to contact us.
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