PARP inhibitor A-966492, Purity ≥98%

Synonym: 934162-61-5; A966492; A-966492; 2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide; PARP inhibitor

MDL: MFCD17215207
CAS Number: 934162-61-5
Compound CID: 16666333

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

A-966492, soluble in warmed DMSO and insoluble in water and ethanol, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP1, PARP1, and PARP2.

Molecular Weight

324.4

Molecular Formula

C₁₈H₁₇FN₄O

Targets

PARP1: 1 nM (Ki); PARP1: 1 nM (EC₅₀); PARP2: 1.5 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 60 mg/mL (184.98 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

A-966492 can be used to explore its potential as a PARP inhibitor.