Cat. No.: X23-10-ZQ227
PARP inhibitor AG14361, Purity ≥98%
Synonym: 328543-09-5; AG14361; AG-14361; AG 14361; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-; 1-(4-((Dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; PARP inhibitor
- MDL: MFCD18385009
- CAS Number: 328543-09-5
- Compound CID: 9840076
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
AG14361, soluble in DMSO and insoluble in ethanol and water, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP1.
Molecular Formula
C19H20N4O
Targets
PARP1: <5 nM (Ki)
Solubility
DMSO: 11 mg/mL (34.33 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
AG14361 can be used to study the role of PARP inhibition in enhancing radiosensitivity in cancer cells.
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