Cat. No.: X23-10-ZQ227
PARP inhibitor AG14361, Purity ≥98%
Synonym: 328543-09-5; AG14361; AG-14361; AG 14361; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-; 1-(4-((Dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; PARP inhibitor
- MDL: MFCD18385009
- CAS Number: 328543-09-5
- Compound CID: 9840076
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
AG14361, soluble in DMSO and insoluble in ethanol and water, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP1.
Molecular Formula
C19H20N4O
Targets
PARP1: <5 nM (Ki)
Solubility
DMSO: 11 mg/mL (34.33 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AG14361 can be used to study the role of PARP inhibition in enhancing radiosensitivity in cancer cells.
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