PARP inhibitor ME0328, Purity ≥98%

Synonym: 1445251-22-8; ME0328; ME-0328; 3-(4-oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1S)-1-phenylethyl]propanamide; (S)-3-(4-oxo-3,4-Dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide; 3-(4-oxo-3H-QUINAZOLIN-2-YL)-N-[(1S)-1-PHENYLETHYL]PROPANAMIDE; PARP inhibitor

CAS Number: 1445251-22-8
Compound CID: 135566764

Product Size

25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ME0328, soluble in DMSO and insoluble in ethanol and water, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP3 and PARP1.

Molecular Weight

321.37

Molecular Formula

C₁₉H₁₉N₃O₂

Targets

PARP3: 0.89 μM; PARP1: 6.3 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 60 mg/mL (186.69 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ME0328 can be used to explore its potential as a proteasome inhibitor in cancer research.