Properties
Description
ME0328, soluble in DMSO and insoluble in ethanol and water, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP3 and PARP1.
Molecular Formula
C19H19N3O2
Targets
PARP3: 0.89 μM; PARP1: 6.3 μM
Solubility
DMSO: 60 mg/mL (186.69 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ME0328 can be used to explore its potential as a proteasome inhibitor in cancer research.