PARP inhibitor Olaparib, Purity ≥98%

Synonym: 763113-22-0; Olaparib; Lynparza; AZD2281; KU-0059436; AZD-2281; AZD 2281; 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one; PARP inhibitor

MDL: MFCD13185161
CAS Number: 763113-22-0
Compound CID: 23725625

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Olaparib, soluble in warmed DMSO and water and insoluble in ethanol, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP2, PARP1, and Tankyrase-1.

Molecular Weight

434.5

Molecular Formula

C₂₄H₂₃FN₄O₃

Targets

PARP2: 1 nM; PARP1: 5 nM; Tankyrase-1: 1.5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 74 mg/mL (170.32 mM); Water: <1 mg/mL; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Olaparib can be used to investigate its effects as a PARP inhibitor in BRCA-mutated cancers.