PDGFR inhibitor AB1010, Purity ≥98%

Synonym: 790299-79-5; PDGFR inhibitor; AB1010; Masivet

MDL: MFCD09954132
CAS Number: 790299-79-5
Compound CID: 10074640

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AB1010, soluble in DMSO and ethanol and insoluble in water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets LynB, PDGFRα, Abl1, Akt1, Bmx, BTK, c-Fms, c-Met, c-Ret, EGFR, and Fes.

Molecular Weight

498.6

Molecular Formula

C₂₈H₃₀N₆OS

Targets

LynB: 510 nM; PDGFRα: 540 nM; Abl1: 1.20 μM; Akt1: >10 μM; Bmx: >10 μM; BTK: >10 μM; c-Fms; c-Met: >10 μM; c-Ret: >10 μM; EGFR: >10 μM; Fes: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 91 mg/mL (182.49 mM); Water: Insoluble; Ethanol: 4 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

AB1010, or Masitinib, is a PDGFR inhibitor in investigations into cancer therapeutics.