PDGFR inhibitor ABT-869, Purity ≥98%

Synonym: 796967-16-3; PDGFR inhibitor; ABT869; ABT-869

MDL: MFCD11840918
CAS Number: 796967-16-3
Compound CID: 11485656

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ABT-869, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets CSF-1R, VEGFR2/KDR, Akt, c-Met, Cdc2, EGFR, FGFR, FGR, FLT3, Fyn, and Hck.

Molecular Weight

375.4

Molecular Formula

C₂₁H₁₈FN₅O

Targets

CSF-1R: 3 nM; VEGFR2/KDR: 4 nM; Akt: >50 μM; c-Met: >50 μM; Cdc2: 9.8 μM; EGFR: >50 μM; FGFR: >12.5 μM; FGR: >50 μM; FLT3: 4 nM; Fyn: >50 μM; Hck: >50 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 73 mg/mL (194.45 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ABT-869 serves as a PDGFR inhibitor in research exploring mechanisms of tumor growth control.