PDGFR inhibitor AV-951, Purity ≥98%

Synonym: 475108-18-0; PDGFR inhibitor; AV-951; AV951

MDL: MFCD15146788
CAS Number: 475108-18-0
Compound CID: 9911830

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

AV-951, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets EphB2, VEGFR3, Abl, c-Kit, c-Met, EGFR, EphB4, ErbB2, ErbB4, FAK, and FGFR1.

Molecular Weight

454.9

Molecular Formula

C₂₂H₁₉ClN₄O₅

Targets

EphB2: 24 nM; VEGFR3: 15 nM; Abl: 620 nM; c-Kit: 78 nM; c-Met: 550 nM; EGFR: >1 μM; EphB4: 480 nM; ErbB2: >1 μM; ErbB4: >1 μM; FAK: >1 μM; FGFR1: 530 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 19 mg/mL (41.76 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AV-951 inhibits PDGFR, contributing to research focused on therapeutic strategies targeting PDGFR-associated malignancies.