PDGFR inhibitor Avapritinib, Purity ≥98%

Synonym: 1703793-34-3; PDGFR inhibitor; BLU-285; BLU 285; BLU285

MDL: MFCD31544325
CAS Number: 1703793-34-3
Compound CID: 118023034

Product Size

1 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Avapritinib, soluble in DMSO and ethanol and insoluble in water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets c-Kit, Flt3, PDGFRβ, and VEGFR2.

Molecular Weight

498.56

Molecular Formula

C₂₆H₂₇FN₁₀

Targets

c-Kit: 9 nM; Flt3: 7 nM; PDGFRβ: 4 nM; VEGFR2: 8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 61 mg/mL (122.35 mM); Water: Insoluble; Ethanol: 3 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Avapritinib inhibits PDGFR, which is critical for research on treating tumors driven by abnormal platelet-derived growth factor receptors.