PDGFR inhibitor CP-673451, Purity ≥98%

Synonym: 343787-29-1; PDGFR inhibitor; CP673451

CAS Number: 343787-29-1
Compound CID: 10158940

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CP-673451, soluble in warmed DMSO and ethanol and insoluble in water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets c-Kit, PDGFRα, bFGFR, c-Met, EGFR, ErbB2, IGF-1R, LCK, PDGFRβ, Src, and Tie-2.

Molecular Weight

417.5

Molecular Formula

C₂₄H₂₇N₅O₂

Targets

c-Kit: 252 nM; PDGFRα: 10 nM; bFGFR: >5 μM; c-Met: >10 μM; EGFR: >10 μM; ErbB2: >10 μM; IGF-1R: >10 μM; LCK: >1 μM; PDGFRβ: 1 μM; Src: >2 μM; Tie-2: >5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 28 mg/mL (67.06 mM); Water: Insoluble; Ethanol: 4 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

CP-673451 acts as a PDGFR inhibitor, contributing to research on pathways involved in cancerous cell proliferation.