PDGFR inhibitor Imatinib mesylate, Purity ≥98%

Synonym: 220127-57-1; PDGFR inhibitor; Gleevec; Glivec; CGP-57148B; STI-571

MDL: MFCD04307699
CAS Number: 220127-57-1
Compound CID: 123596

Product Size

100 mg; 200 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Imatinib mesylate, soluble in DMSO and water and insoluble in ethanol, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets c-Kit (M-07e cells), PDGFR, and v-Abl.

Molecular Weight

589.7

Molecular Formula

C₂₉H₃₁N₇O.CH₄SO₃

Targets

c-Kit (M-07e cells): 100 nM; PDGFR: 100 nM; v-Abl: 600 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 101 mg/mL (171.26 mM); Water: 101 mg/mL (171.26 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Imatinib mesylate is applied as a PDGFR inhibitor in research focused on cancer treatment mechanisms involving PDGFR blockade.