PDGFR inhibitor Ki8751, Purity ≥98%

Synonym: 228559-41-9; PDGFR inhibitor; Ki-8751

MDL: MFCD09971092
CAS Number: 228559-41-9
Compound CID: 11317348

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Ki8751, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets c-Kit, PDGFRα, EGFR, FGFR2, HGFR, Insulin receptor, and VEGFR2.

Molecular Weight

469.4

Molecular Formula

C₂₄H₁₈F₃N₃O₄

Targets

c-Kit: 40 nM; PDGFRα: 67 nM; EGFR: >10 μM; FGFR2: 170 nM; HGFR: >10 μM; Insulin receptor: >10 μM; VEGFR2: 0.9 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 46 mg/mL (97.99 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Ki8751 is used as a PDGFR inhibitor to facilitate research on therapies that impede cancer growth via PDGFR pathways.