PDGFR inhibitor KRN 633, Purity ≥98%

Synonym: 286370-15-8; PDGFR inhibitor; KRN633; KRN-633

MDL: MFCD14155620
CAS Number: 286370-15-8
Compound CID: 9549295

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

KRN 633, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets VEGFR1, VEGFR2, BTK, c-Kit, PDGFRα, PDGFRβ, Tie-2, and VEGFR3.

Molecular Weight

416.9

Molecular Formula

C₂₀H₂₁ClN₄O₄

Targets

VEGFR1: 170 nM; VEGFR2: 160 nM; BTK: 9200 nM; c-Kit: 4330 nM; PDGFRα: 965 nM; PDGFRβ: 9850 nM; Tie-2: 9900 nM; VEGFR3: 125 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 8 mg/mL (19.18 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

KRN 633 acts as a PDGFR inhibitor, supporting research into therapies that hinder cancer progression through growth factor signaling.