PDGFR inhibitor MP470, Purity ≥98%

Synonym: 850879-09-3; PDGFR inhibitor; Amuvatinib

MDL: MFCD16038298
CAS Number: 850879-09-3
Compound CID: 11282283

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

MP470, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets c-Kit (D816H), FLT3 (D835Y), and PDGFRα (V561D).

Molecular Weight

447.5

Molecular Formula

C₂₃H₂₁N₅O₃S

Targets

c-Kit (D816H): 10 nM; FLT3 (D835Y): 81 nM; PDGFRα (V561D): 40 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 30 mg/mL (67.03 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

MP470 inhibits PDGFR, aiding research in developing cancer treatments by targeting signaling pathways.