Properties
Description
STI571, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets c-Kit (M-07e cells), PDGFR, and v-Abl.
Molecular Formula
C29H31N7O
Targets
c-Kit (M-07e cells): 100 nM; PDGFR: 100 nM; v-Abl: 600 nM
Solubility
DMSO: 28 mg/mL (56.72 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
STI571, known as Imatinib, is a PDGFR inhibitor crucial for research on chronic diseases like leukemia and cancer.