PDGFR inhibitor Sunitinib malate, Purity ≥98%

Synonym: 341031-54-7; PDGFR inhibitor; SU-11248

MDL: MFCD08282795
CAS Number: 341031-54-7
Compound CID: 6456015

Product Size

50 mg; 100 mg; 200 mg; 500 mg

Price

Datasheet

MSDS

Properties

Description

Sunitinib malate, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets FLT3, PDGFRβ, EGFR, FGFR1, Kit, and VEGFR2.

Molecular Weight

532.6

Molecular Formula

C₂₂H₂₇FN₄O₂.C₄H₆O₅

Targets

FLT3; PDGFRβ: 2 nM; EGFR: >20 μM; FGFR1: 2.9 μM; Kit; VEGFR2: 80 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 13 mg/mL (24.41 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Sunitinib malate is utilized to study and inhibit PDGFR, which contributes to understanding tumor growth and angiogenesis.