PDGFR inhibitor Toceranib phosphate, Purity ≥98%

Synonym: 874819-74-6; PDGFR inhibitor; SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639

MDL: MFCD25372034
CAS Number: 874819-74-6
Compound CID: 16034840

Product Size

10 mg; 50 mg; 200 mg

Price

Datasheet

MSDS

Properties

Description

Toceranib phosphate, soluble in DMSO and water and insoluble in ethanol, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets Flk-1 and PDGFRβ.

Molecular Weight

494.45

Molecular Formula

C₂₂H₂₈FN₄O₆P

Targets

Flk-1: 6 nM (Ki); PDGFRβ: 5 nM (Ki)

Form

Lyophilized powder

Purity

Solubility

DMSO: 2 mg/mL (4.04 mM); Water: 2 mg/mL (4.04 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Toceranib phosphate is leveraged as a PDGFR inhibitor in research focused on canine tumors and comparative oncology.