PDK1 inhibitor BX-795, Purity ≥98%

Synonym: 702675-74-9; BX795; BX-795; BX 795; N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-1-PYRROLIDINECARBOXAMIDE; N-(3-((5-Iodo-4-((3-(thiophene-2-carboxamido)propyl)amino)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide; PDK1 inhibitor

MDL: MFCD12546134
CAS Number: 702675-74-9
Compound CID: 10077147

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BX-795, soluble in DMSO and insoluble in ethanol and water, is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells. It targets cKit, PDK1, CDK2/CyclinE, Chk1, EGFR, GSK-3β, Insulin receptor, KDR, PKA, PKC, and T-Fyn.

Molecular Weight

591.5

Molecular Formula

C₂₃H₂₆IN₇O₂S

Targets

cKit: 320 nM; PDK1: 6 nM; CDK2/CyclinE: 430 nM; Chk1: 510 nM; EGFR: >10 μM; GSK-3β: 620 nM; Insulin receptor: >10 μM; KDR: 1.1 μM; PKA: 840 nM; PKC: 9.3 μM; T-Fyn: 6.4 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (148.78 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

BX-795 can be utilized to study its inhibition of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in cancer and inflammatory disease models.