PDK1 inhibitor BX-912, Purity ≥98%

Synonym: 702674-56-4; BX912; PDK1 inhibitor

CAS Number: 702674-56-4
Compound CID: 11754511

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BX-912, soluble in DMSO and ethanol and insoluble in water, is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells. It targets KDR, PKA, c-Kit, CDK2/CyclinE, Chk1, EGFR, GSK-3β, InsulinReceptor, PDK-1, PKC, and T-Fyn.

Molecular Weight

471.4

Molecular Formula

C₂₀H₂₃BrN₈O

Targets

KDR: 410 nM; PKA: 110 nM; c-Kit: 850 nM; CDK2/CyclinE: 650 nM; Chk1: 830 nM; EGFR: >10 μM; GSK-3β: 7.4 μM; InsulinReceptor: 6.1 μM; PDK-1: 12 μM; PKC: 1.25 μM; T-Fyn: 2.1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (169.72 mM); Water: Insoluble; Ethanol: 80 mg/mL (169.72 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BX-912 is used to inhibit PDK1 activity, assisting in the exploration of PI3K/AKT signaling in cancer.