PERK inhibitor GSK2606414, Purity ≥98%

Synonym: 1337531-36-8; GSK2606414; GSK 2606414; GSK-2606414; 1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone; PERK inhibitor

MDL: MFCD25976926
CAS Number: 1337531-36-8
Compound CID: 53469448

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK2606414, soluble in DMSO and ethanol and insoluble in water, disrupts UPR pathway, potentially affecting apoptosis through various downstream effects. It targets EIF2AK3 (PERK), EIF2AK1 (HRI), and EIF2AK2 (PKR).

Molecular Weight

451.44

Molecular Formula

C₂₄H₂₀F₃N₅O

Targets

EIF2AK3 (PERK): 0.4 nM; EIF2AK1 (HRI): 420 nM; EIF2AK2 (PKR): 696 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (192.71 mM); Water: Insoluble; Ethanol: 18 mg/mL (39.87 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

GSK2606414 can be used to study the inhibition of the PERK pathway and its effects on cell survival in cancer research.

Storage

Store at -20ºC.