PERK inhibitor ISRIB, Purity ≥98%

Synonym: 1597403-47-8; 548470-11-7; 1597403-48-9; ISRIB; Trans-ISRIB; ISRIB (trans-isomer); N,N'-(cis-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide); PERK inhibitor

MDL: MFCD27952932; MFCD30730068
CAS Number: 1597403-47-8
Compound CID: 1011240

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ISRIB, soluble in DMSO and insoluble in ethanol and water, disrupts UPR pathway, potentially affecting apoptosis through various downstream effects. It targets PERK.

Molecular Weight

451.34

Molecular Formula

C₂₂H₂₄Cl₂N₂O₄

Targets

PERK: 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 4 mg/mL (8.86 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ISRIB can be employed to research the regulation of protein synthesis and stress responses in disease models.