Properties
Description
ISRIB, soluble in DMSO and insoluble in ethanol and water, disrupts UPR pathway, potentially affecting apoptosis through various downstream effects. It targets PERK.
Molecular Formula
C22H24Cl2N2O4
Solubility
DMSO: 4 mg/mL (8.86 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ISRIB can be employed to research the regulation of protein synthesis and stress responses in disease models.
