PERK inhibitor Salubrinal, Purity ≥98%

Synonym: 405060-95-9; Salubrinal; J8PSF5Z8KJ; N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide; (E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide; 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide; PERK inhibitor

MDL: MFCD00548612
CAS Number: 405060-95-9
Compound CID: 5717801

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Salubrinal, soluble in DMSO and ethanol and insoluble in water, disrupts UPR pathway, potentially affecting apoptosis through various downstream effects. It targets eIF2α.

Molecular Weight

479.81

Molecular Formula

C₂₁H₁₇N₄OSCl₃

Targets

eIF2α

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (179.23 mM); Water: Insoluble; Ethanol: 2 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Salubrinal can be employed to investigate the ER stress pathway and its implications in treating diseases such as cancer.

Storage

Store at -20ºC.