Properties
Description
3-Methyladenine, soluble in warmed DMSO, warmed water and ethanol, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kγ (HeLa cells) and Vps34 (HeLa cells).
Targets
PI3Kγ (HeLa cells): 60 μM; Vps34 (HeLa cells): 25 μM
Solubility
Warmed DMSO: 3 mg/mL (20.11 mM); Warmed water: 10 mg/mL (67.04 mM); Ethanol: 4 mg/mL (26.81 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
3-Methyladenine is employed primarily as an autophagy inhibitor, used to investigate the role of autophagy in cellular processes and disease models.
