PI3K inhibitor A66, Purity ≥98%

Synonym: 1166227-08-2; A-66; PI3K inhibitor

CAS Number: 1166227-08-2
Compound CID: 42636535

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

A66, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110α, p110α E545K, p110α H1047R, p110γ, PI3K-C2β, and PI3K-C2β.

Molecular Weight

393.53

Molecular Formula

C₁₇H₂₃N₅O₂S₂

Targets

p110α: 32 nM; p110α E545K: 30 nM; p110α H1047R: 43 nM; p110γ: 3480 nM; PI3K-C2β: 462 nM; PI3K-C2β: 236 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (195.66 mM); Water: Insoluble; Ethanol: 1 mg/mL (2.54 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

A66 is used in research to study its specific inhibition of the p110α isoform of PI3K, aiding in the understanding of PI3K signaling in cancer and metabolism.