Properties
Description
A66, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110α, p110α E545K, p110α H1047R, p110γ, PI3K-C2β, and PI3K-C2β.
Molecular Formula
C17H23N5O2S2
Targets
p110α: 32 nM; p110α E545K: 30 nM; p110α H1047R: 43 nM; p110γ: 3480 nM; PI3K-C2β: 462 nM; PI3K-C2β: 236 nM
Solubility
DMSO: 77 mg/mL (195.66 mM); Water: Insoluble; Ethanol: 1 mg/mL (2.54 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
A66 is used in research to study its specific inhibition of the p110α isoform of PI3K, aiding in the understanding of PI3K signaling in cancer and metabolism.
