Properties
Description
Acalisib, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets DNA-PK, hVps34, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C21H16FN7O
Targets
DNA-PK: 18749 nM; hVps34: 12682 nM; PI3Kα: 5441 nM; PI3Kβ: 3377 nM; PI3Kδ: 12.7 nM; PI3Kγ: 1389 nM
Solubility
DMSO: 76 mg/mL (189.34 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Acalisib is utilized in research for its selective inhibition of PI3K δ, useful in studying B-cell malignancies and autoimmune conditions.
