PI3K inhibitor Acalisib, Purity ≥98%

Synonym: 870281-34-8; GS-9820; PI3K inhibitor

CAS Number: 870281-34-8
Compound CID: 11618268

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Acalisib, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets DNA-PK, hVps34, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

401.4

Molecular Formula

C₂₁H₁₆FN₇O

Targets

DNA-PK: 18749 nM; hVps34: 12682 nM; PI3Kα: 5441 nM; PI3Kβ: 3377 nM; PI3Kδ: 12.7 nM; PI3Kγ: 1389 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 76 mg/mL (189.34 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Acalisib is utilized in research for its selective inhibition of PI3K δ, useful in studying B-cell malignancies and autoimmune conditions.