Properties
Description
Alpelisib hydrochloride is a potent compound that inhibits PI3 kinase activity. It targets p110α, p110α-E545K, p110α-H1047R, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C19H23ClF3N5O2S
Targets
p110α: 5 nM; p110α-E545K: 4 nM; p110α-H1047R: 4 nM; PI3Kβ: 1200 nM; PI3Kδ: 290 nM; PI3Kγ: 250 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Alpelisib hydrochloride is used to explore its efficacy as a PI3Kα inhibitor in the context of understanding and treating PI3Kα-driven cancers.
