PI3K inhibitor AZD8186, Purity ≥98%

Synonym: 1627494-13-6; AZD 8186; AZD-8186; PI3K inhibitor

CAS Number: 1627494-13-6
Compound CID: 52913813

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

AZD8186, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kβ, PI3Kδ, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

457.47

Molecular Formula

C₂₄H₂₅F₂N₃O₄

Targets

PI3Kβ: 4 nM; PI3Kδ: 12 nM; PI3Kα: 35 nM; PI3Kβ: 3 nM; PI3Kδ: 17 nM; PI3Kγ: 675 nM

Form

Lyophilized powder

Purity

Solubility

Warmed DMSO: 82 mg/mL (179.25 mM); Water: Insoluble; Warmed ethanol: 32 mg/mL (69.94 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD8186 is researched for its dual PI3K β and δ inhibitory properties, important in exploring treatment avenues for PTEN-deficient cancers.