Properties
Description
AZD8186, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kβ, PI3Kδ, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C24H25F2N3O4
Targets
PI3Kβ: 4 nM; PI3Kδ: 12 nM; PI3Kα: 35 nM; PI3Kβ: 3 nM; PI3Kδ: 17 nM; PI3Kγ: 675 nM
Solubility
Warmed DMSO: 82 mg/mL (179.25 mM); Water: Insoluble; Warmed ethanol: 32 mg/mL (69.94 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZD8186 is researched for its dual PI3K β and δ inhibitory properties, important in exploring treatment avenues for PTEN-deficient cancers.
