Properties
Description
AZD8835, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kα-E545K, PI3Kα-H1047R, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C22H31N9O3
Targets
PI3Kα: 6.2 nM; PI3Kα-E545K: 6 nM; PI3Kα-H1047R: 5.8 nM; PI3Kβ: 431 nM; PI3Kδ: 5.7 nM; PI3Kγ: 90 nM
Solubility
DMSO: 83 mg/mL (176.76 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZD8835 is utilized to understand the dual inhibition of PI3K α and δ, providing insights into its therapeutic potential in cancers with PI3K pathway dysregulation.
