PI3K inhibitor AZD8835, Purity ≥98%

Synonym: 1620576-64-8; AZD 8835; AZD-8835; PI3K inhibitor

CAS Number: 1620576-64-8
Compound CID: 76685059

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD8835, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kα-E545K, PI3Kα-H1047R, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

469.54

Molecular Formula

C₂₂H₃₁N₉O₃

Targets

PI3Kα: 6.2 nM; PI3Kα-E545K: 6 nM; PI3Kα-H1047R: 5.8 nM; PI3Kβ: 431 nM; PI3Kδ: 5.7 nM; PI3Kγ: 90 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 83 mg/mL (176.76 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD8835 is utilized to understand the dual inhibition of PI3K α and δ, providing insights into its therapeutic potential in cancers with PI3K pathway dysregulation.