Properties
Description
BAY 80-6946, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets mTOR, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C23H28N8O4
Targets
mTOR: 45 nM; PI3Kα: 0.5 nM; PI3Kβ: 3.7 nM; PI3Kδ: 0.7 nM; PI3Kγ: 6.4 nM
Solubility
DMSO: Insoluble; Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BAY 80-6946, also known as copanlisib, is studied for its selective inhibition of PI3K α and δ isoforms, relevant for treating hematological malignancies and solid tumors.
