PI3K inhibitor BEZ235, Purity ≥98%

Synonym: 915019-65-7; NVP-BEZ235; Dactolisib; PI3K inhibitor

CAS Number: 915019-65-7
Compound CID: 11977753

Product Size

25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BEZ235, soluble in DMSO and warmed ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets mTOR (p70S6K), p110γ, Akt1/PKBα, ATR, B-Raf (V599E), c-Abl, c-Met, c-Src, CDK1, EGFR/ErbB1, and EphB4.

Molecular Weight

469.6

Molecular Formula

C₃₀H₂₃N₅O

Targets

mTOR (p70S6K): 6 nM; p110γ: 5 nM; Akt1/PKBα: >10 μM; ATR: 21 nM; B-Raf (V599E): >10 μM; c-Abl: >10 μM; c-Met: >10 μM; c-Src: >10 μM; CDK1: >10 μM; EGFR/ErbB1: >8.5 μM; EphB4: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: <1 mg/mL; Water: Insoluble; Warmed ethanol: 16 mg/mL (34.07 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BEZ235 can be used to investigate its dual PI3K/mTOR inhibition for potential anticancer treatment.