Properties
Description
BKM120, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110β, p110δ, DNA-PK, mTOR, p110α, p110γ, PI4Kβ, and Vps34.
Molecular Formula
C18H21F3N6O2
Targets
p110β: 166 nM; p110δ: 116 nM; DNA-PK: >5 μM; mTOR: 4.6 μM; p110α: 52 nM; p110γ: 262 nM; PI4Kβ: >25 μM; Vps34: 2.4 μM
Solubility
DMSO: 76 mg/mL (185.18 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BKM120 is employed in research as a pan-PI3K inhibitor, aiding in the study of PI3K's role in cancer progression and therapy.
