PI3K inhibitor BKM120, Purity ≥98%

Synonym: 944396-07-0; NVP-BKM120; Buparlisib; PI3K inhibitor

CAS Number: 944396-07-0
Compound CID: 16654980

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BKM120, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110β, p110δ, DNA-PK, mTOR, p110α, p110γ, PI4Kβ, and Vps34.

Molecular Weight

410.4

Molecular Formula

C₁₈H₂₁F₃N₆O₂

Targets

p110β: 166 nM; p110δ: 116 nM; DNA-PK: >5 μM; mTOR: 4.6 μM; p110α: 52 nM; p110γ: 262 nM; PI4Kβ: >25 μM; Vps34: 2.4 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 76 mg/mL (185.18 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.87 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BKM120 is employed in research as a pan-PI3K inhibitor, aiding in the study of PI3K's role in cancer progression and therapy.