Properties
Description
CAL-101, soluble in warmed DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110β, p110γ, C2β, DNA-PK, hVPS34, mTOR, p110α, p110δ, PIP5Kα, and PIP5Kβ.
Molecular Formula
C22H18FN7O
Targets
p110β: 565 nM; p110γ: 89 nM; C2β: >1 μM; DNA-PK: 6.729 μM; hVPS34: 978 nM; mTOR: >1 μM; p110α: 820 nM; p110δ: 2.5 nM; PIP5Kα: >1 μM; PIP5Kβ: >1 μM
Solubility
Warmed DMSO: 76 mg/mL (182.94 mM); Water: Insoluble; Ethanol: 21 mg/mL (50.55 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CAL-101, known as idelalisib, is utilized to study its role as a PI3K δ inhibitor, especially in B-cell malignancies.
