PI3K inhibitor CAL-101, Purity ≥98%

Synonym: 870281-82-6; CAL101; GS-1101; Idelalisib; PI3K inhibitor

CAS Number: 870281-82-6
Compound CID: 11625818

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CAL-101, soluble in warmed DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110β, p110γ, C2β, DNA-PK, hVPS34, mTOR, p110α, p110δ, PIP5Kα, and PIP5Kβ.

Molecular Weight

415.4

Molecular Formula

C₂₂H₁₈FN₇O

Targets

p110β: 565 nM; p110γ: 89 nM; C2β: >1 μM; DNA-PK: 6.729 μM; hVPS34: 978 nM; mTOR: >1 μM; p110α: 820 nM; p110δ: 2.5 nM; PIP5Kα: >1 μM; PIP5Kβ: >1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 76 mg/mL (182.94 mM); Water: Insoluble; Ethanol: 21 mg/mL (50.55 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

CAL-101, known as idelalisib, is utilized to study its role as a PI3K δ inhibitor, especially in B-cell malignancies.