PI3K inhibitor dactolisib tosylate, Purity ≥98%

Synonym: 1028385-32-1; BEZ235 (Tosylate); NVP-BEZ 235 (Tosylate); PI3K inhibitor

CAS Number: 1028385-32-1
Compound CID: 49803145

Product Size

50 mg; 100 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dactolisib tosylate is a potent compound that inhibits PI3 kinase activity. It targets Autophagy, mTOR, mTORC1, mTORC2, p110α, p110α-E545K, p110α-H1047R, p110β, p110δ, and p110γ.

Molecular Weight

641.74

Molecular Formula

C₃₇H₃₁N₅O₄S

Targets

Autophagy; mTOR: 20.7 nM; mTORC1; mTORC2; p110α: 4 nM; p110α-E545K: 5.7 nM; p110α-H1047R: 4.6 nM; p110β: 75 nM; p110δ: 7 nM; p110γ: 5 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

Dactolisib tosylate can be used to study the dual inhibition of PI3K/mTOR in cancer and other proliferative disorders.