Properties
Description
ETP-46321 is a potent compound that inhibits PI3 kinase activity. It targets p110α, p110β, p110δ, p110γ, PI3Kα-E542K, PI3Kα-E542K, and PI3Kα-H1047R.
Molecular Formula
C20H27N9O3S
Targets
p110α: 2.3 nM (Ki); p110β: 170 nM (Ki); p110δ: 14.2 nM (Ki); p110γ: 179 nM (Ki); PI3Kα-E542K: 1.89 nM (Ki); PI3Kα-E542K: 1.77 nM (Ki); PI3Kα-H1047R: 2.33 nM (Ki)
Identity
Confirmed by NMR/HPLC/MS.
Applications
ETP-46321 can be used for the study of dual PI3K/mTOR pathway inhibition, which is significant in cancer therapy research.
