Properties
Description
GNE 477, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets mTOR and PI3Kα.
Molecular Formula
C21H28N8O3S2
Targets
mTOR: 21 nM (Ki); PI3Kα: 4 nM
Solubility
DMSO: 24 mg/mL (47.56 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
GNE 477 can be used to investigate the inhibition of PI3K/mTOR pathways in cancer research.
