Properties
Description
GNE-493, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets mTOR, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C17H20N6O2S
Targets
mTOR: 30 nM; PI3Kα: 3.4 nM; PI3Kβ: 12 nM; PI3Kδ: 16 nM; PI3Kγ: 16 nM
Solubility
DMSO: 63 mg/mL (169.15 mM); Water: Insoluble; Ethanol: 1 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
GNE-493 can be used to explore its properties as a dual PI3K/mTOR inhibitor in cancer studies.
