PI3K inhibitor GSK2126458, Purity ≥98%

Synonym: 1086062-66-9; GSK-2126458; Omipalisib; PI3K inhibitor

CAS Number: 1086062-66-9
Compound CID: 25167777

Product Size

2 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK2126458, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets p110δ, p110γ, mTORC1, mTORC2, p110α, and p110β.

Molecular Weight

505.5

Molecular Formula

C₂₅H₁₇F₂N₅O₃S

Targets

p110δ: 0.024 nM (Ki); p110γ: 0.06 nM (Ki); mTORC1: 0.18 nM (Ki); mTORC2: 0.3 nM (Ki); p110α: 0.019 nM (Ki); p110β: 0.13 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 96 mg/mL (189.91 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK2126458 can be used to investigate dual PI3K/mTOR inhibition for potential anticancer therapy.