PI3K inhibitor IPI-145, Purity ≥98%

Synonym: 1201438-56-3; Duvelisib; IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197; PI3K inhibitor

CAS Number: 1201438-56-3
Compound CID: 50905713

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

IPI-145, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kδ, PI3Kγ, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

416.86

Molecular Formula

C₂₂H₁₇ClN₆O

Targets

PI3Kδ: 23 pM (Ki); PI3Kγ: 243pM (Ki); PI3Kα: 25900 pM (Ki); PI3Kβ: 1564pM (Ki); PI3Kδ: 23pM (Ki); PI3Kγ: 243pM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 76 mg/mL (182.31 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

IPI-145 is used to evaluate dual inhibition of PI3K-δ and PI3K-γ isoforms, important for researching blood cancers.

Storage

Store at -20ºC.