Properties
Description
NVP-BKM120 hydrochloride is a potent compound that inhibits PI3 kinase activity. It targets mTOR, p110α, p110α-E545K, p110α-H1047R, p110β, p110δ, p110γ, and Vps34.
Molecular Formula
C18H21F3N6O2.HCl
Targets
mTOR: 4.6 μM; p110α: 52 μM; p110α-E545K: 4.6 μM; p110α-H1047R: 99 nM; p110β: 166 nM; p110δ: 116 nM; p110γ: 262 μM; Vps34: 2.4 μM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
NVP-BKM120 hydrochloride targets PI3K for studying cancer cell proliferation and survival.