PI3K inhibitor PKI-402, Purity ≥98%

Synonym: 1173204-81-3; PKI402; PI3K inhibitor

CAS Number: 1173204-81-3
Compound CID: 44187953

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PKI-402, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets mTOR, PI3Kα, PI3Kα-E545K, PI3Kα-H1047R, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

570.7

Molecular Formula

C₂₉H₃₄N₁₀O₃

Targets

mTOR: 3 nM; PI3Kα: 2 nM; PI3Kα-E545K: 3 nM; PI3Kα-H1047R: 3 nM; PI3Kβ: 7 nM; PI3Kδ: 14 nM; PI3Kγ: 16 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 0.35 mg/mL (0.61 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PKI-402 is utilized to investigate the dual inhibition of PI3K and mTOR pathways and their potential therapeutic applications in cancer.