Properties
Description
PKI-402, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets mTOR, PI3Kα, PI3Kα-E545K, PI3Kα-H1047R, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C29H34N10O3
Targets
mTOR: 3 nM; PI3Kα: 2 nM; PI3Kα-E545K: 3 nM; PI3Kα-H1047R: 3 nM; PI3Kβ: 7 nM; PI3Kδ: 14 nM; PI3Kγ: 16 nM
Solubility
DMSO: 0.35 mg/mL (0.61 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
PKI-402 is utilized to investigate the dual inhibition of PI3K and mTOR pathways and their potential therapeutic applications in cancer.
